A tetracycline-inducible and skeletal muscle-specific Cre recombinase transgenic mouse
نویسندگان
چکیده
منابع مشابه
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model.
To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the kidney androgen-regulated protein (KAP) promoter. The transgene was expressed in the kidney of male mice but not in female mice. Treatment of female transgenic mice with androgen induced robust expression of the transgene in the kidney....
متن کاملInnovative Methodology An androgen-inducible proximal tubule-specific Cre recombinase transgenic model
Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgeninducible proximal tubule-specific Cre recombinase transgenic model. Am J Physiol Renal Physiol 294: F1481–F1486, 2008. First published April 2, 2008; doi:10.1152/ajprenal.00064.2008.—To facilitate the study of renal proximal tubules, we generated a transgenic mouse strain expressing an improved Cre recombinase (iCre) under the control of the...
متن کاملCerebellar granule cell-specific and inducible expression of Cre recombinase in the mouse.
To develop a cell type-specific and temporal regulation system of gene targeting in the cerebellum, we used the NMDA-type glutamate receptor GluRepsilon3 subunit gene and Cre recombinase-progesterone receptor fusion (CrePR) gene in combination. Injection of the CrePR gene placed under the control of the 10 kb 5' region of the GluRepsilon3 gene into C57BL/6 eggs yielded the ECP25 line that stron...
متن کاملPodocyte-specific expression of tamoxifen-inducible Cre recombinase in mice.
BACKGROUND Podocytes play an important role in maintaining normal glomerular function. A podocyte-specific conditional knockout technology has been established by the use of transgenic mice expressing a podocyte-specific Cre recombinase to clarify the role of genes expressed in the podocytes. However, it may be difficult to examine the role of genes in certain pathologic conditions using conven...
متن کاملMouse opsin promoter-directed Cre recombinase expression in transgenic mice.
PURPOSE Gene inactivation with homologous recombination in mice is a widely used tool to study gene function. However, many proteins play essential roles in a number of tissues and germline gene inactivation often results in embryonic lethality. To overcome this limitation and to dissect the functions of essential genes beyond embryonic development, we generated mouse rod opsin promoter-control...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2009
ISSN: 1932-8451,1932-846X
DOI: 10.1002/dneu.20714